TechTalk Blog
VITP Blood Donor Challenge
When: January 29, 2008 at 10:00 am to January 29, 2008 at 4:00 pm  
Where: Vancouver Island Technology Park Conference Room #2201 – 4464 Markham Street

Description:
Join us for some friendly competition to help save lives!

Every minute of every day, someone in Canada needs blood. Daily there are hundreds of procedures that occur in hospitals which could not happen without blood donors. A recent survey showed that more than half of Canadians say they, or a family member, has needed blood.

You can do something to help. Your participation and involvement in the VITP Blood Donor Challenge will help Canadian Blood Services ensure that the critical needs of British Columbians are met.

Challenge Highlights:

Recruit friends and family
Employees can earn donations for their organizations by donating blood themselves, and/or by recruiting friends and family to donate on their behalf. All donations made at the VITP Blood Donor Clinic on Tuesday, January 29th, 2008 are eligible to be included in the challenge.

Help save lives
Through just one blood donation your unique and individual gift has the potential to save up to three lives and make a direct and positive impact on your community.

Prizes
A plaque will be awarded to the organization with the highest staff participation rate.

Where Can I donate?
Donations can be made in the conference centre of the Park. Please remember to sign the Partners for Life binder at the refreshment area to ensure your donation counts towards this challenge.

If you want to make a group booking, please call Catherine @405-4308 or Catherine.sloot@blood.ca. If you want to come on your own, please call 1 888 2 DONATE to book an appointment or speak to a nurse regarding your eligibility to donor or visit www.blood.ca.

2008 Life Sciences British Columbia Awards – Nominations Now Open

Nominations are now open for the 10th annual Life Sciences British Columbia Awards!

The deadline for submission is February 28th, 2008, so don't delay in sending your nomination.

You all know a deserving member of British Columbia's life sciences community, so we ask you to make sure they are nominated. The nomination process is open to LifeSciences BC members and non-members alike, and you can nominate another company or person you feel excels in the areas described, or submit an application for your own company. Please note that all awards are open to all BC life sciences sectors.

Awards will be made in the following categories:

Executive of the Year
Genome BC Award for Scientific Excellence
Industry Communication Award
Innovation and Achievement
Leadership Award
Life Sciences Company of the Year
Emerging Life Sciences Company of the Year
Medical Device Company of the Year
Lifetime Achievement

For more information, download the nomination guidelines and form here.

Ticket sales for the 2008 Awards Ceremony to be held April 10th are now open – please click here for details.

Research Triangle Park Leader Rick Weddle Elected President of IASP North American Division

RESEARCH TRIANGLE PARK, NC – Rick Weddle, President and CEO of The Research Triangle Park, was elected President of the North American Division of the International Association of Science Parks (IASP) during a division meeting hosted by Quebec Metro High Tech Park in Quebec, Canada in December. During his two-year term as North American Division President, Mr. Weddle will serve on IASP’s esteemed International Board of Directors, comprised of science park leaders from around the globe.

“It is an honor to serve on this prestigious international board and to collaborate with IASP and global science park leaders,” said Weddle. “IASP underscores the importance of research, science and technology parks as successful tools for regional economic transformation.”

The International Association of Science Parks is an international non-profit association dedicated to assisting the development of new science and technology parks as well as the growth and internationalization of already mature projects, encouraging partnerships and fostering international networking among more than 300 member organizations, represented by over 65 countries. The Research Triangle Park is an active member of IASP and will host the 2009 IASP World Conference, coinciding with the 50th anniversary year of The Research Triangle Park’s establishment. The world conference, scheduled for June 2009, is expected to draw more than 1,000 international attendees to the Research Triangle region.

Detailed planning for the 2009 IASP World Conference will accelerate during the first quarter of 2008. The new, 500,000 square foot, state-of-the-art Raleigh Convention Center that will debut this year will be the primary conference venue.

“We are excited to ramp up plans to bring the 2009 IASP World Conference to the Triangle,” said Weddle. “The year 2009 is an historic one marked not only by RTP’s 50th anniversary, but also by significant milestones for many of our regional partners. Together with our partners and sponsors we look forward to showcasing our vibrant region to the IASP global delegation in 2009.”

Reuters Reports: U.S. Company Claims Cloned Humans, Made Stem Cells

Maggie Fox, Reuters
Published: Thursday, January 17, 2008

WASHINGTON – A California company said on Thursday it used cloning technology to make five human embryos, with the eventual hope of making matched stem cells for patients.

Stemagen Corp. in La Jolla, California, destroyed the embryos while testing to make sure they were true clones. But the researchers, based at a fertility center, said they believed their ready source of new human eggs would make their venture a success.

Other experts were skeptical about the claims, published in the journal Stem Cells. If verified, the team would be the first to prove they have cloned human beings as a source of stem cells, the master cells of the body.

The Stemagen team said they got five human embryos using skin cells from two adult men who work at the IVF center. They said they had painstakingly verified that the embryos were clones of the two men.

"We hope it is a bit of a turning point for many more studies," Andrew French, who led the research, said in a telephone interview.

They used a technique called somatic cell nuclear transfer, or SCNT, which involves hollowing out an egg cell and injecting the nucleus of a cell from the donor to be copied — in this case, the skin cells from the men.

It is the same technique used to make Dolly the sheep in 1996, the first mammal to be cloned from an adult. Researchers hope to use the technique to create tailor-made transplants of cells, tissue or organs for patients, treating injuries and diseases like juvenile diabetes.

"Since a significant percentage of couples undergoing fertility treatments appear willing to participate in this type of research, we believe the method described to obtain donated oocytes is a viable and ethically acceptable strategy," the researchers wrote.

MOST SUCCESSFUL SO FAR

Some cloning experts said the work appeared to be genuine.

"This is the most successful description so far of the use of the cloning techniques with purely human material. However, it is still a long way from achieving the goal of obtaining embryonic stem cells," said Robin Lovell-Badge of Britain's Medical Research Council's division of stem cell biology.

"I hope that the authors have the opportunity to continue their work and derive embryo stem cell lines," Ian Wilmut, who led the team that cloned Dolly and who is now at the University of Edinburgh, said in an e-mail.

The field is controversial for several reasons.

President George W. Bush opposes the use of human embryos to make stem cells and has vetoed bills from Congress that would expand federal funding of this research.

South Korean scientist Hwang Woo-suk made headlines when he was found to have faked key parts of a report that his team had used cloning technology to make human embryos in 2004.

"We need to be ultra-cautious after the Hwang scandal and not make the same mistake all over again," said Dr. Robert Lanza of Advanced Cell Technology, a Massachusetts company that is also trying to make human embryonic stem cells. "I'd really like to believe it, but I'm not sold yet," Lanza said.

Other teams have made stem cells they believe are similar to embryonic cells using a variety of techniques, including reprogramming a human egg cell alone, reprogramming ordinary skin cells into what are called induced pluripotent stem cells, or by taking one cell from a human embryo without harming the embryo.

But most stem cell experts agree it is important to continue trying to make stem cells from embryos too.

Miners' Group Contributes to UBC Earth Sciences

The Province

Published: Tuesday, January 15, 2008

A group of mining companies announced yesterday it has given more than $20 million to the University of B.C to help it build a new earth-systems science building. The $75-million facility, set to begin construction next year, will house UBC's earth and ocean sciences department.

Goldcorp, Lundin Group and Pan American Silver Corp. are among the industry leaders who have ponied up more than $20 million of the $32.5 million in private-sector funding for the building's construction.

"As an international leader in earth sciences, UBC has helped to shape Vancouver into a world-renowned centre for mineral exploration and development," said Pan American Silver chairman Ross Beaty.

"Vancouver is home to more mineral-resource companies than any other city in the world and further creation of opportunities for future geologists, geophysicists, geochemists and geological engineers is critical to sustaining B.C.'s — and indeed Canada's — minerals industry."

Science faculty dean Simon Peacock said the new building "represents an investment in the future of the Canadian and international mineral exploration communities . . . The ESS Building will provide undergraduate and graduate students a world-class education in the earth sciences."

The building, set to open in 2011, will accommodate the more than 6,000 undergraduate and graduate students currently enrolled in EOS courses.

Donors include Breakwater Resources Ltd., Northern Peru Copper Corp., Catherine McLeod-Seltzer, Global Copper Corp., Ross Beaty, Selwyn Resources Ltd., Imperial Metals Corp., Silver Standard Resources Inc., Silver Wheaton Corp., Northern Dynasty Minerals Ltd. and Western Copper Corp.

Transit Plan to Help B.C. Reach Greenhouse Gas Targets

Premier Gordon Campbell and Transportation Minister Kevin Falcon unveiled a $14-billion public transit plan to be completed by 2020 today. It is a key measure in the Province’s greenhouse gas reduction plan, touching every region of the province.
 
“Our new plan will double transit ridership by increasing choice for people around the province, with new fleets, green technology, new lines and new innovative services like RapidBus BC,” Campbell said. “The plan focuses on safe, comfortable, reliable services that will highlight green technologies and will reshape our communities by encouraging integration of work, home and recreational activities. It provides people with the choices they need to make a difference.”
 
“One new transit line was committed to in each of the previous three decades; this plan delivers three lines in the next decade,” said Falcon.
 
The plan calls for $14 billion in investments, including $11.1 billion in new funding, with the Province committing $4.75 billion, and the remainder from partners, including the federal government, TransLink and local governments.
 
Increased security measures will enhance transit safety. Electronic gates and closed-circuit cameras will be installed at rapid transit and new RapidBus stations. A smart-card system for rapid transit and buses, which users can reload at vending machines or on the Internet, will be implemented.
 
“This plan will provide fast, reliable, green transit that acts as a catalyst to change the nature and form of all our communities – urban, suburban and rural,” said Campbell. “As more and more British Columbians live and work near transit, urban form will shift, which will lead to lower energy use, increasing energy efficiency, and a lighter environmental footprint.”
 
A cumulative total of 4.7 million tonnes in transportation greenhouse gases (GHG) will be reduced by 2020. The GHG savings will be about the equivalent of parking all the cars and light trucks in Metro Vancouver for a full year by getting British Columbians out of their cars and onto transit.
 
The plan calls for: 

  • $10.3-billion investment in four new rapid transit lines in Metro Vancouver – the Evergreen Line, the UBC Line, the upgraded Expo Line and the Canada Line (for which $2 billion was previously committed);
  • $1.2 billion for a new, cutting-edge energy efficient, high capacity RapidBus BC service along nine major routes in the high-growth urban centres of Kelowna, Victoria and Metro Vancouver; and 
  • $1.6-billion investment in 1,500 new, clean energy buses and related maintenance infrastructure to provide communities around the province with improved bus service.  

“The transit plan sets out innovative, integrated, customized solutions for individual communities to keep people and goods moving efficiently in B.C. as part of our broader transportation strategy,” said Falcon. “Increased transit will allow people more choice, and often time savings. For example, during peak periods, transit riders travelling between Coquitlam Centre and Vancouver International Airport can save more than an hour every day compared to drivers.” 
 
The Transit Plan complements other key provincial transportation initiatives such as the Cariboo Connector, Trans-Canada Highway upgrades like the Kicking Horse Canyon, roads to support the mountain pine beetle harvest, and projects in Metro Vancouver such as the Gateway Program. This announcement is in addition to the recently announced $180-million investment establishing rapid bus service over the Gateway Program’s twinned Port Mann Bridge. 
 

 

Backgrounder

Comprehensive New Transit Plan Benefits Entire Province

 

Key Objectives

  • Increase transit ridership across the province to over 400 million trips a year. 
  • Reduce greenhouse gas (GHG) emissions and other air contaminants from cars by 4.7 million tonnes cumulatively by 2020. 
  • Support increased population and employment densities near transit hubs and along transit corridors, changing urban forms, which will further decrease GHG emissions. 
  • For Metro Vancouver, the transit market share will grow from 12 per cent during weekdays today to 17 per cent by 2020 and to 22 per cent by 2030. 
  • For the Victoria Regional Transit System, the transit market share will grow from today’s seven per cent to 9.5 per cent by 2020 and 12 per cent by 2030. 
  • For other regions of the province, the transit market share will grow from today’s three per cent to four per cent in 2020 and five per cent in 2030. 
  • Ease traffic congestion and make all our communities healthier places to live and easier places to get around.  
  • Provide transit riders with access to more buses, more often. 
  • Upgrade our provincial bus fleet with 1,500 new, clean energy buses and related maintenance infrastructure, 
  • Increase the hours of service. 
  • Create long-term partnerships to maximize taxpayer investments and meet specific needs of specific communities in cost-effective, energy efficient ways. 
  • Improve transit rider safety and comfort with improved security on and around transit, particularly rapid transit, and increase fare compliance. 
  • Increase seniors’ mobility options and improve services for those with mobility challenges. 

Costs for Major Transit Improvements

  • $1.6 billion for 1,500 new, clean technology buses to add nearly 60 per cent more buses to the provincial fleet and provide communities in British Columbia more frequent service to meet transit users’ specific needs.
  • $10.3 billion for four new and expanded rapid transit lines serving communities across Metro Vancouver – the Evergreen Line, the UBC Line, the upgraded Expo Line, and the Canada Line (previously committed funding totalling $2 billion for which B.C. is providing $435 million). 
  • $1.2 billion for new RapidBus BC lines – energy efficient, high capacity buses on nine major routes in the high growth urban centres of Kelowna, Victoria and Metro Vancouver, providing frequent, fast, reliable service that looks and feels like rapid transit and operates on dedicated lane-ways in some cases. 

Other Benefits

  • Increased security measures such as installing electronic gates and closed-circuit cameras at rapid transit stations and using a smart-card system for rapid transit and buses that users can reload at vending machines or on the Internet.
  • New, customized solutions for individual communities across the province, including more HandyDART, community shuttles, conventional buses and other technologies. 

Financial Requirements 

  • $11.1 billion in new funding is required from all partners.
  • he estimated provincial share of funding – over 40 per cent of new funding – is $4.75 billion by 2020. 
  • Over the life of the plan from now until 2020, the Province is calling on the federal government for investments of $3.1 billion, TransLink for investments of $2.75 billion, and local governments for investments of $500 million along with supportive land use. 
  • In total, $14 billion in funding is required through 2020. 
Vancouver Sun Reports" 'Ready to Rocket' in 2008

25 B.C. tech firms named to this year's list of right technologies at the right time

 

By Gillian Shaw 

The soaring Canadian dollar and growing fears of a U.S. recession are failing to stall 25 B.C. technology companies being touted as 'Ready to Rocket' in 2008.

And despite an unfavourable economic climate in their most important export market, companies named to last year's list by tech consultants Rocket Builders chalked up a whopping median revenue growth rate of 75 per cent, outstripping the previous growth record of 60 per cent.

That compares to an overall growth rate in the information technology sector of five to six per cent, and it bodes well for the 2008 cohort that has been led in growth by two companies that share analytics as a common theme.

The first, 90 Degree Software, specializes in business reporting software, and the other, Vision Critical Communications, led by CEO Angus Reid, offers market research.

"They were head and shoulders above the other companies in terms of growth," said Geoffrey Hansen, managing partner of Rocket Builders, who declined to disclose the exact growth rates for the private companies.

Hansen said he was surprised at the final growth stats for the 2007 list, tech companies that collectively accounted for 300 new hires in B.C. last year, with a median employment growth of 22 per cent.

"That's a pretty good hit for the economy from 25 companies," he said. "I was worried last year about what would happen if the Canadian dollar got stronger and the U.S. dollar weakened, but it seems these companies are not worried about that.

"Even though the U.S. economy is slowing, our best median growth in past years was 60 per cent. And now it is 75 per cent."

An office-in-a-box has propelled newcomer Burnaby's Sutus Inc. onto the 2008 list, which included eight companies named as 'Ready to Rocket' for the first time.

"Our secret sauce is our user interface – we have a three-page set-up guide," Shawn Chute, executive vice-president of Sutus, said of his company's product that handles the entire communications – voice, data and networking – needs for offices ranging in size from three to 25 people.

"You can set up a 10-person office in under an hour," said Chute.

The company, which has 28 employees, has garnered just over $11 million from venture capitalists who see a rosy future for it. And Hansen named Sutus as a potential target for a larger company.

"They are quite an exciting company, and you have to think some of the bigger companies are going to want to go after that space in the future," he said.

Kelowna-based TRFind Systems, an up-and-coming company that was formed in 2005 and specializes in RFID (radio frequency identification) in industrial manufacturing, made this year's list and is representative of tech growth outside the Lower Mainland.

GenoLogics Life Science Software, another company on the list and one that develops software to manage scientific data and lab operations, is on Vancouver Island, an area that is home to a growing number of tech companies.

Among the 25 companies on the 2008 list, Hansen said 68 per cent are focused on the U.S. for their growth, 20 per cent are focused on Europe and the Middle East, and remainder see Canada as their key market.

Among the newcomers this year are two companies in the electronic payments business – hyperWALLET Systems, which focuses on electronic, global payment systems, and the parking payment company Digital Payment Technologies.

"They have been around for a while, but now the market for the technologies has taken off," said Hansen. "I guess the financial community is more used to accepting different ways of payment.

"It's amazing how fast they are growing."

 

B.C.'s Climate Law to be North America's Toughest

Business Examiner (Vancouver Island)

B.C.'s lofty goal to get rid of a third of its greenhouse gas emissions in the next 13 years
is well within reach, says a key member of the provincial government's new climate
action team.
Andrew Weaver, Canada research chair in atmospheric science at the University of
Victoria, says North America's most ambitious short-term target can be reached mainly
with education and tax incentives to help people choose energy-efficient vehicles and
lifestyles.
"Thirty-three per cent is not that difficult," said Weaver, who shared the recent Nobel
Prize for his work on United Nations climate reports. "For many people, it's about saving
money."
Premier Gordon Campbell introduced the 22-member advisory team Tuesday, and
Environment Minister Barry Penner introduced legislation that will require the first target
to be met by 2020. By 2050, the law will require 80 per cent of emissions to be gone,
which implies a huge transformation of the B.C. economy.
The government has given itself until the end of 2008 to set interim targets for 2012 and
2016, based on options set out by the climate action team. The mix of mostly scientific
and industry representatives in the group offers some indication of where it may go.
Named as a special advisor is Mark Jaccard, a resource economist at Simon Fraser
University and former chair of the B.C. Utilities Commission. He argued in a recent book
that greenhouse gases are most likely to be controlled by using fossil fuels and capturing
their carbon emissions, rather than converting to entirely new energy sources.
Also named to the team is 100 Mile House Mayor Donna Barnett, who chairs the Cariboo
Chilcotin Beetle Action Coalition. Weaver and other leading climate scientists stress that
the past century of industrialization has already loaded the atmosphere with enough
carbon dioxide and other insulating gases that coping with things like insect outbreaks
and flooding must be part of any strategy.
Premier Gordon Campbell said there has to be a long-term approach.
"If we try and tell people we can do this in 13 months, we're not going to be successful,"
Campbell said. "What we've said initially is we're going to do it in 13 years. And as Bill
Page 13 of 17
Gates once said, we'll accomplish way less in two years than we expect, and way more in
10."
NDP environment critic Shane Simpson said he is concerned that the climate action
team's recommendations may not be fully made public, and that important viewpoints are
not represented.
"There's nobody representing local government from a larger urban centre where most of
your challenges are around transportation, around growth, around urban sustainability
issues," Simpson said, adding that Peter Robinson, incoming CEO of the David Suzuki
Foundation, is the only environmentalist on the list.
Penner acknowledged that much of the B.C. plan depends on regulations that have not yet
been created.
"Because this is an evolving science we need to have some flexibility to incorporate the
information we're going to be getting from the climate action team," he said.
Penner said B.C.'s target for 2020 is the highest in North America, exceeding California's
while matching its commitment to enshrine it in law.
"The climate change specialists say anything between 60 to 90 per cent is what they're
looking for to try and stabilize global greenhouse gas emissions by 2050, so this bill gives
us the legal imperative to do that," Penner said.

Aspreva Pharmaceuticals Change Name to Vifor Pharma – Aspreva

Aspreva Pharmaceuticals Corporation today announced the completion of the plan of arrangement with Galencia Group, pursuant to which Galencia, through a wholly-owned Canadian subsidiary, acquired all outstanding shares of Aspreva for US $26.00 per share in cash.

With the completion of the plan of arrangement, Aspreva will delist its shares from the NASDAQ on January 3, 2008 and the Toronto Stock Exchange on January 7, 2008.

Effective immediately, Aspreva Pharmaceuticals will now be named Vifor Pharma Aspreva.

  
  

Protox Announces Positive Final Results from BPH Study
 Protox(TM) Therapeutics Inc. (TSX-V: PRX), a 
 leader in advancing novel, targeted protein toxin therapeutics for the 
 treatment of cancer and other proliferative diseases, today announced positive 
 final results from its Phase 1 study evaluating PRX302 in patients with benign 
 prostatic hyperplasia (BPH), a common condition among the aging male 
 population. The trial results indicate that PRX302 is safe and well tolerated 
 and shows very promising signs of therapeutic activity for the treatment of 
 BPH. 
     "The impact of PRX302 in the quality of life of most patients has been 
 dramatic," commented Dr. Peter Pommerville, co-principal investigator at 
 Can-Med Clinical Research Centre in Victoria, B.C. "In addition to the rapid 
 treatment response, the effect of PRX302 continued to improve with time and 
 showed that symptomatic relief was sustained over time. Furthermore, patient 
 satisfaction with the single ten minute office-based minimally invasive 
 treatment for BPH is high." 
     "We are very pleased with these data as PRX302 continues to deliver 
 impressive results in the clinic," said Dr. Fahar Merchant, President and 
 Chief Executive Officer of Protox. "In addition to the excellent safety and 
 tolerability profile, PRX302 has demonstrated substantial symptomatic benefit 
 in most patients who failed existing oral therapies." 
   
     Study Design: 
   
     This study was an open-label, multi-centre, dose escalation study where 
 the primary endpoint was safety and tolerability following a single 
 intra-prostatic administration of PRX302. The secondary endpoint was to 
 determine therapeutic activity as measured by the change in International 
 Prostate Symptom Score (IPSS) throughout the study, when compared to 
 screening. In addition, changes in Quality of Life (QoL) scores, prostate 
 volume and uroflow parameters were also monitored. A total of 15 patients with 
 moderate to severe BPH were treated in this trial. The dose was increased 
 14-fold between cohort 1 and cohort 4, keeping the dosing volume constant, 
 whereas one additional cohort received cohort 1 dose at a 4-fold higher 
 volume. Patient parameters at screening were as follows: age - 64.8 years 
 (range: 52-82); prostate size - 41.3 mL (range: 30.0-80.1); IPSS - 19.1 
 (range: 12-26); QoL - 4.3 (range: 3-6). Most patients treated in this study 
 were either refractory or intolerant to oral therapy. 
   
     Study Results: 
   
     Despite a 14-fold escalation in dose, no safety issues were identified 
 and the maximum tolerated dose was not reached in this study. Results indicate 
 that PRX302 was well tolerated with no serious adverse events observed. 
 Treatment related adverse events were generally reported as being mild, local 
 and transient in nature. 
     Therapeutic activity of PRX302 was evaluated at day-30 and day-90 
 post-treatment using standardized symptom indices, namely, IPSS and QoL. IPSS 
 assesses the severity of seven key symptoms of BPH, (incomplete emptying, 
 frequency, intermittency, urgency, weak stream, straining and nocturia). The 
 QoL score is measured on a scale from 0-6 with 0 defined as "delighted" and 6 
 defined as "terrible" with respect to patient quality of life due to BPH. 
     Treatment related symptomatic relief was rapid and substantial benefits 
 were noticed by day-30 post-treatment. Both symptom scores (IPSS and QoL) 
 continued to show further improvements in all cohorts at the end of the active 
 study period (day-90 post-treatment) indicating a potential for sustained 
 benefit following a single treatment with PRX302. 
     Across all treatment groups, IPSS scores showed a statistically 
 significant improvement from screening to Day 30 (p (less than) 0.01) and 
 continued to Day 90 post-treatment (p (less than) 0.001). The mean IPSS values 
 improved by an average of 5.8 points from 19.1 +/- 4.3 at screening to 14.3 
 +/- 5.7 at day-30 post treatment. By day-90, IPSS improved by an average of 
 8.5 points (10.6 - 5.9) with 8 of 15 patients showing a 10 point or greater 
 improvement in IPSS values. The improvements were observed across all seven 
 symptom sub-scores, each decreasing by at least 30%. Although early, these 
 results are compelling especially when a reduction in IPSS by greater than 
 four points is deemed to be highly clinically significant. 
     Improvement in QoL scores were observed in all five cohorts. Independent 
 of the treatment group, QoL scores improved from an average of 4.3 +/- 1.1 at 
 screening to 2.5 +/- 1.6 by day-30 (p (less than) 0.01) and continued to show 
 a 50% improvement by day-90 (QoL = 2.1 - 1.6; p (less than) 0.01)). 
 Furthermore, prostate volume decreased in all cohorts.
 Irrespective of cohort 
 assignment, the mean prostate volume decreased by over 26% from 41.6 cc at 
 screening to 30.5 cc at day-90 post-treatment (p (less than) 0.05). 
     Based on the encouraging data from this study, plans are currently 
 underway to commence a Phase 2 BPH clinical trial in the first quarter of 
 2008.